BBMRI-omics: Introduction and Hands-on Application

March 30, 31 and April 7, 2017 – Utrecht

During a 2-days program researchers can get acquainted with the data BBMRI-omics has on offer for the research community.

On the first day, a series of lectures will introduce the wide spectrum of -omics data present within BBMRI (from genomics to metabolomics, from methylomics to transcriptomics), and how this data infrastructure will help unraveling disease mechanisms and risk stratification.

On the second day, researchers with knowledge of the data analysis software R can follow a hands-on course to learn how to access and analyze the multiple omics data within BBMRI-omics.

Registration is closed.

Do you have any questions or do you want to change your registration? Please contact Rick Jansen via email: Ri.Jansen@ggzingeest.nl.

Updated: 29-03-2017

Program

Day 1
Presentations
March 30
Venue: Vergadercentrum Vredenburg
, Vredenburg 19, 3511BB Utrecht

09:30 – 10:00  Welcome with coffee and tea
10:00 – 10:30  Eline Slagboom: Introduction to BBMRI-Omics.nl
10:30 – 11:00  Cornelia van Duijn: Use of metabolomics in disease risk prediction
11:00 – 11:30  Coffee and tea
11:30 – 12:00  Bas Heijmans: Cross-omics atlases
12:00 – 12:30  Lude Frank: Allele specific expression
12:30 – 14:00  Lunch
14:00 – 14:30  Aad van der Lugt: -Omics and imaging
14:30 – 15:00  Dorret Boomsma: -Omics and behaviour
15:00 – 15:30  Sasha Zhernakova: -Omics and gut microbiome
15:30 – 17:00  Drinks

 

Day 2
Hands-on Course
March 31 / April 7
Venue: SURF, Room 3.5, Offices Hoog Overborch (Hoog Catharijne), Moreelsepark 48, 3511EP Utrecht

10:00 – 10:15
Introduction to available omics data within BBMRI-omics. Description of RNA-seq, 450k methylation, metabolomics, imputed genotypes, phenotypes and technical covariates. Data location and access. (Rick Jansen)

10:15 – 10:45
Introduction to R package BIOSRutils. How to use BIOSRutils for filtering and QC, and finally run EWAS and TWAS (Maarten van Iterson)

10:45 – 11:45
Practicum (Maarten van Iterson)

11:45 – 12:30
Lunch (demo: using BBMRI-omics online atlases (Jan-Bert van Klinken))

12:30 – 13:00
Joost Verlouw: QTL lookup of GWAS hits. Take the SNP hits from a recent GWAS, extract corresponding BIOS genotype data, run association with full Methylation, Expression and Metabolomics data sets.

13:00 – 14:00

Practicum (Joost Verlouw)

14:00 – 14:15

Tea break

14:15 – 14:45

Introduction to the Brainshake 1H-NMR metabolomics platform (Marian Beekman)

14:45 – 15.30

Practicum. Analyzing Metabolomics data (Koen Dekker)

15:30 – 16:00

Allele specific expression (Niek de Klein & Freerk van Dijk)

16:00 – 17:00

Practicum (Niek de Klein & Freerk van Dijk)

17:00
Drinks