Article describes the importance of cohort studies in the post-GWAS era

A huge progress has been made in identifying genetic variants that modify individuals’ predisposition to common diseases. Unfortunately, the understanding of these genetic variants remains limited. In this article, opportunities for using large-scale cohort studies, to investigate the downstream molecular effects of SNPs at different ‘omics’ data levels are discussed. The authors see a pivotal role for population cohorts, such as those connected in BBMRI-NL, in establishing causality and advancing drug discovery.

Read the article published in Nature Genetics.