BBMRI-Omics is the joint collection of omics data that has collaboratively been generated and that is made available for BBMRI researchers focusing on integrative omics studies in Dutch Biobanks.
BBMRI-Omics Warehouse with available data resources
DNA Genetic Variation has been generated within the Genome of the Netherlands (GoNL) consortium using Whole Genome Sequencing with Illumina Hiseq technology.
Gene expression data has been generated within the Biobank-based Integrative Omics Studies Consortium (BIOS) consortium using Illumina RNA sequencing technology.
DNA methylation data has been generated within the Biobank-based Integrative Omics Studies Consortium (BIOS) consortium using Illumina 450K array technology.
In the future, BBMRI-Omics intend to extend the collection of omics data with MRI imaging data and gut microbiome data.
The mission of BBMRI-Omics is to create a large-scale data infrastructure and to bring together BBMRI researchers focusing on integrative omics studies in Dutch Biobanks. Currently over 23 Dutch cohorts are sharing their data within BBMRI-Omics, which consists of omics data in over 26,000 samples.
Overview of number of samples per omics data type
For an overview of the numbers per omics data type per cohort, please follow this link.
Participating Cohorts and their Characteristics
|VUNTR||Netherlands Twin Register||link|
|NESDA||Netherlands Study of Depression and Anxiety||link|
|HELIUS||Healthy Life in an Urban Setting||link|
|CHECK||Cohort Heup En Cohort Knie|
|STEMI_GIPS-III||Glycometabolic Intervention as adjunct to Primary percutaneous intervention in ST elevation myocardial infarction|
|LLS_PARTOFFS||Leiden Longevity Study (Offspring and their partners)||link|
|GARP||Genetics of ARthritis en Progression||link|
|CODAM||Cohort on Diabetes and Atherosclerosis Maastricht|
|BIOMARCS||BIOMarker study to identify the Acute risk of a Coronary Syndrome||link|
|DMS||De Maastricht Studie||link|
|DZS_WF||Diabetes ZorgSysteem West Friesland||link|
|UCORBIO||Utrecht Coronary Biobank|
|ERF_ERGO||Erasmus Rotterdam Gezondheid Onderzoek (Rotterdam Studie)||link|
|ALPHAOMEGA||Alpha Omega Trial||link|
|PROSPER||Prospective Study of Pravastatin in the Elderly at Risk|
|LLS_SIBS||Leiden Longevity Study (Nonagenarians)||link|
Access to BBMRI-Omics data using a centralized computational facility
In the near future we will have 1 data access procedure, but currently you still have to follow the separate data access procedures:
For access to the Whole Genome Sequencing data, please go to the GoNL page.
For access to Gene Expression or DNA methylation data, please go to the BIOS consortium page.
For access to the Metabolomics data, please go to the Metabolomics Consortium page.
The BBMRI BIOS consortium has in parallel with the Metabolomics Consortium generated DNA Methylation and Gene expression data. At the wiki http://wiki.bbmri.nl/wiki/BIOS_start- which is created by the BBMRI BIOS consortium you can also find all the information concerning data requests, access and processing.
BBMRI-Omics Management Team
P. Eline Slagboom1, Dorret I. Boomsma2, Cornelia van Duijn3
- Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
- Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
- Department of Genetic Epidemiology, ErasmusMC, Rotterdam, The Netherlands
29 March 2017