Publications 2016

We have listed only items that contain BBMRI-NL or the grant number in the affiliation, funding and/or acknowledgement section of the article. Items are listed per year in alphabetical order.

  • Abubakar M, Orr N, Daley F, Coulson P, Ali HR, Blows F, Benitez J, Milne R, Brenner H, Stegmaier C, et al.: Prognostic value of automated ki67 scoring in breast cancer: A centralised evaluation of 8088 patients from 10 study groups. Breast Cancer Research 18(1): 104.
  • Abubakar M, Howat WJ, Daley F, Zabaglo L, McDuffus LA, Blows F, Coulson P, Raza Ali H, Benitez J, Milne R, et al.: High-throughput automated scoring of ki67 in breast cancer tissue microarrays from the breast cancer association consortium. The Journal of Pathology: Clinical Research 2(3): 138-153.
  • Adams HHH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Renteria ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivieres S, et al.: Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience 19(12): 1569-1582.
  • Aguirre-Gamboa R, Joosten I, Urbano PCM, van der Molen RG, van Rijssen E, van Cranenbroek B, Oosting M, Smeekens S, Jaeger M, Zorro M, et al.: Differential effects of environmental and genetic factors on t and b cell immune traits. Cell Reports 17(9): 2474-2487.
  • Akker van den EB, Pitts SJ, Deelen J, Moed MH, Potluri S, van Rooij J, Suchiman HED, Lakenberg N, De Dijcker WJ, Uitterlinden AG, et al.: Uncompromised 10-year survival of oldest old carrying somatic mutations in dnmt3a and tet2. Blood 127(11): 1512-1515.
  • Amin N, Allebrandt KV, van der Spek A, Muller-Myhsok B, Hek K, Teder-Laving M, Hayward C, Esko T, van Mill JG, Mbarek H, et al.: Genetic variants in RBFOX3 are associated with sleep latency. European Journal of Human Genetics 24(10): 1488-1495.
  • Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, et al.: Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics 48(12): 1462-1472.
  • Beekman M, Uh HW, van Heemst D, Wuhrer M, Ruhaak LR, GonzalezCovarrubias V, Hankemeier T, Houwing-Duistermaat JJ, Slagboom PE: Classification for longevity potential: The use of novel biomarkers. Front Public Health 4: 233.
  • Berg van den SM, de Moor MHM, Verweij KJH, Krueger RF, Luciano M, Vasquez AA, Matteson LK, Derringer J, Esko T, Amin N, et al.: Metaanalysis of genome-wide association studies for extraversion: Findings from the genetics of personality consortium. Behavior Genetics 46(2): 170-182.
  • Boelema SR, Harakeh Z, van Zandvoort MJ, Reijneveld SA, Verhulst FC, Ormel J, Vollebergh WA: Executive functioning before and after onset of alcohol use disorder in adolescence. A TRAILS study. J Psychiatr Res 78: 78-85.
  • Bonder MJ, Kurilshikov A, Tigchelaar EF, Mujagic Z, Imhann F, Vila AV, Deelen P, Vatanen T, Schirmer M, Smeekens SP, et al.: The effect of host genetics on the gut microbiome. Nature Genetics 48(11): 1407- 1412.
  • Bonvanie IJ, Oldehinkel AJ, Rosmalen JGM, Janssens KAM: Sleep problems and pain: A longitudinal cohort study in emerging adults. Pain 157(4): 957-963.
  • Bot M, Middeldorp C, de Geus EJ, Lau HM, Sinke M, van Nieuwenhuizen B, Smit J, Boomsma DI, Penninx BWJH: Selfreported online assessment of lifetime major depressive disorder: A validation study. Bipolar Disorders 18: 128-128.
  • Bot M, Thesing C, Penninx BWJH: Associations between plasma metabolites and major depressive disorder. Bipolar Disorders 18: 137-137.
  • Bovenberg J, Kattenberg M, Baselmans BM, Sinke M, Hoekstra R, Boomsma DI, Willemsen G: Enhancing biobank participants’ rights – from paper to portal Scripted 13(1): 70-82.
  • Braak van den RRJC, Vink GR, van Oijen MGH, de Noo ME, Kurk SA, Burbach MJP, Couwenberg AM, May AM, Verkooijen HM, Meijer GA, et al.: The prospective Dutch colorectal cancer cohort: A prospective nation-wide observational cohort study. Cancer Research 76(14 Suppl): 1827.
  • Brankovic M, Akkerhuis KM, Buljubasic N, Cheng JM, Oemrawsingh RM, Garcia-Garcia HM, Regar E, Serruys PW, van Geuns RJ, Boersma E, et al.: Plasma cystatin c and neutrophil gelatinase-associated lipocalin in relation to coronary atherosclerosis on intravascular ultrasound and cardiovascular outcome: Impact of kidney function (ATHEROREMO-IVUS study). Atherosclerosis 254: 20-27.
  • Brouwers MCG, Simons N, Schaper NC, Stehouwe CDA, van Greevenbroek MMJ: Nonalcoholic fatty liver disease is associated with incident type 2 diabetes in combined hyperlipidaemic pedigrees: A 10-years follow-up study. Diabetologia 59: S147-S147.
  • Castano-Betancourt MC, Evans DS, Ramos YFM, Boer CG, Metrustry S, Liu YF, den Hollander W, van Rooij J, Kraus VB, Yau MS, et al.: Novel genetic variants for cartilage thickness and hip osteoarthritis. PLoS Genetics 12(10): e1006260
  • Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Consortium of Modifiers of BRCA, Hollestelle A, van der Baan FH, Berchuck A, Johnatty SE, Aben KK, Agnarsson BA, Aittomaki K, et al.: No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. Gynecol Oncol 141(2): 386-401.
  • Darabi H, Beesley J, Droit A, Kar S, Nord S, Marjaneh MM, Soucy P, Michailidou K, Ghoussaini M, Wahl HF, et al.: Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the collaborative oncological gene-environment study (cogs). Scientific Reports 6: 32512.
  • Deelen J, van den Akker EB, Trompet S, van Heemst D, Mooijaart SP, Slagboom PE, Beekman M: Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity. Exp Gerontol 82: 166-174.
  • Dekkers KF, Slagboom PE, Jukema JW, Heijmans BT: The multifaceted interplay between lipids and epigenetics. Current Opinion in Lipidology 27(3): 288-294.
  • Dekkers KF, van Iterson M, Slieker RC, Moed MH, Bonder MJ, van Galen M, Mei HL, Zhernakova DV, van den Berg LH, Deelen J, et al.: Blood lipids influence DNA methylation in circulating cells. Genome Biology 17: 12.
  • Deutekom van AW, Chinapaw MJ, Gademan MG, Twisk JW, Gemke RJ, Vrijkotte TG: The association of birth weight and infant growth with childhood autonomic nervous system activity and its mediating effects on energy-balance-related behaviours-the ABCD study. International Journal of Epidemiology 45(4): 1079-1090.
  • Dongen van J, Nivard MG, Willemsen G, Hottenga JJ, Helmer Q, Dolan CV, Ehli EA, Davies GE, van Iterson M, Breeze CE, et al.: Genetic and environmental influences interact with age and sex in shaping the human methylome. Nature Communications 7: 13.
  • Dooren van FE, Schram MT, Schalkwijk CG, Stehouwer CD, Henry RM, Dagnelie PC, Schaper NC, van der Kallen CJ, Koster A, Sep SJ, et al.: Associations of low grade inflammation and endothelial dysfunction with depression – the Maastricht study. Brain, Behavior, and Immunity 56: 390-396.
  • Dooren van FE, Verhey FR, Pouwer F, Schalkwijk CG, Sep SJ, Stehouwer CD, Henry RM, Dagnelie PC, Schaper NC, van der Kallen CJ, et al.: Association of type d personality with increased vulnerability to depression: Is there a role for inflammation or endothelial dysfunction? – the Maastricht study. Journal of Affective Disorders 189: 118-125.
  • Duijn van CM, van der Lee SJ, Ikram MA, Hofman A, Hankemeier T, Amin N, Demirkan A: Metabolites associated with cognitive function in the Rotterdam study and Erasmus Rucphen family study. Alzheimer's & Dementia 12(7): P165.
  • Easton DF, Lesueur F, Decker B, Michailidou K, Li J, Allen J, Luccarini C, Pooley KA, Shah M, Bolla MK, et al.: No evidence that protein truncating variants in brip1 are associated with breast cancer risk: Implications for gene panel testing. Journal of Medical Genetics 53(5): 298-309.
  • Eicher JD, Chami N, Kacprowski T, Nomura A, Chen MH, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N, et al.: Plateletrelated variants identified by exomechip meta-analysis in 157,293 individuals. American Journal of Human Genetics 99(1): 40-55.
  • Everaerd D, Klumpers F, Zwiers M, Guadalupe T, Franke B, van Oostrom I, Schene A, G. F, Tendolka I: Childhood abuse and deprivation are associated with distinct sex-dependent differences in brain morphology. Neuropsychopharmacology 41(7): 1716-1723.
  • Felix JF, Bradfield JP, Monnereau C, van der Valk RJP, Stergiakouli E, Chesi A, Gaillard R, Feenstra B, Thiering E, Kreiner-Moller E, et al.: Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics 25(2): 389-403.
  • Francioli LC, Cretu-Stancu M, Garimella KV, Fromer M, Kloosterman WP, The Genome of the Netherlands Consortium, Samocha KE, Neale BM, Daly MJ, Banks E, et al.: A framework for the detection of de novo mutations in family-based sequencing data. European Journal of Human Genetics 25(2): 227-233.
  • Franke L, el Bannoudi H, Jansen DT, Kok K, Trynka G, Diogo D, Swertz M, Fransen K, Knevel R, Gutierrez-Achury J, et al.: Association analysis of copy numbers of fc-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes. European Journal of Human Genetics 24(2): 263-270.
  • Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJE, AriasVasquez A, Smoller JW, Nichols TE, Neale MC, et al.: Genetic influences on schizophrenia and subcortical brain volumes: Largescale proof of concept. Nature Neuroscience 19(3): 420-431.
  • Gibson-Smith D, Bot M, Paans NP, Visser M, Brouwer I, Penninx BWJH: The role of obesity measures in the development and persistence of major depressive disorder. J Affect Disord 198: 222-229.
  • Hamdi Y, Soucy P, Adoue V, Michailidou K, Canisius S, Lemacon A, Droit A, Andrulis IL, Anton-Culver H, Arndt V, et al.: Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21. Oncotarget 7(49): 80140-80163.
  • Hehir-Kwa JY, Marschall T, Kloosterman WP, Francioli LC, Baaijens JA, Dijkstra L, Abdellaoui A, Koval V, TjwanThung D, Wardenaar R, et al.: A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population Nature Communications 6(7): 12989.
  • Hehir-Kwa JY, Marschall T, Kloosterman WP, Francioli LC, Baaijens JA, Dijkstra LJ, Abdellaoui A, Koval V, Thung DT, Wardenaar R, et al.: A high-quality human reference panel reveals the complexity and distribution of genomic structural variants. Nature Communications 7(7): 12989.
  • Heleniak C, McLaughlin KA, Ormel J, Riese H: Cardiovascular reactivity as a mechanism linking child trauma to adolescent psychopathology. Biological Psychology 120: 108-119.
  • Hollander den W, Boer CG, Hart D, Yau MS, Ramos YF, Metrustry S, Broer L, Deelen J, Beekman M, Cupples LA, et al.: Novel susceptability loci for osteoarthritis of the hand: Coding variants in MGP and ENPP3. Osteoarthritis and Cartilage 24: S226-S227.
  • Holub P, Swertz M, Reihs R, van Enckevort D, Muller H, Litton JE: BBMRI-ERIC directory: 515 biobanks with over 60 million biological samples. Biopreserv Biobank 14(6): 559-562.
  • Horst ter R, Jaeger M, Smeekens SP, Oosting M, Swertz MA, Li Y, Kumar V, Diavatopoulos DA, Jansen AFM, Lemmers H, et al.: Host and environmental factors influencing individual human cytokine responses. Cell 167(4): 1111-1124.e1113
  • Hulsegge G, Spijkerman AMW, van der Schouw YT, Bakker SJL, Gansevoort RT, Smit HA, Verschuren WMM: Trajectories of metabolic risk factors and biochemical markers prior to the onset of cardiovascular disease - the Doetinchem cohort study. PLoS One 11(5): e0155978.
  • Huttin C, Stubbs A: A contribution for cost models in biobanking. Technology and Health Care 24(1): 93-98.
  • Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C, Walter K, Min JL, Chen L, Astle W, Cocca M, et al.: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nature Genetics 48(11): 1303-1312.
  • Jansen R, Penninx BWJH, Madar V, Xia K, Milaneschi Y, Hottenga JJ, Hammerschlag AR, Beekman A, van der Wee N, Smit JH, et al.: Gene expression in major depressive disorder. Molecular Psychiatry 21(3): 339-347.
  • Jong de K, Vonk JM, Faiz A, van der Plaat DA, Timens W, Bosse Y, Kromhout H, Nedeljkovic I, Postma DS, Boezen HM: Novel genetic susceptibility loci for FEV1 in the context of occupational exposure in never-smokers. Am J Respir Crit Care Med 194(6): 769-772.
  • Jorg F, Visser E, Ormel J, Reijneveld SA, Hartman CA, Oldehinkel AJ: Mental health care use in adolescents with and without mental disorders. Eur Child Adolesc Psychiatry 25(5): 501-508.
  • Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu CJ, et al.: DNA methylation in newborns and maternal smoking in pregnancy: Genome-wide consortium meta-analysis. American Journal of Human Genetics 98(4): 680-696.
  • Kaakinen M, Claringbould A, Hagenbeek F, Magi R, Ala-Korpela M, Jarvelin MR, Prokopenko I, Consortium B: Genome-wide multiphenotype and eQTL analyses provide novel insights into omega fatty acid metabolism and type 2 diabetes. Diabetes 65: A52.
  • Kettunen J, Demirkan A, Wurtz P, Draisma HHM, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikainen LP, Pirinen M, et al.: Genomewide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nature Communications 7: 11122.
  • Kilpelainen TO, Carli JFM, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman AK, Drong AW, Hayes JE, Zhao JH, et al.: Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nature Communications 7: 10494.
  • Klein M, Berger S, Hoogman M, Dammers J, Makkinje R, Heister A, Galesloot TE, Kiemeney L, Weber H, Kittel-Schneider S, et al.: Metaanalysis of the DRD5 VNTR in persistent ADHD. European Neuropsychopharmacology 26(9): 1527-1532.
  • Klinken van JB, van Dijk KW: FluxModeCalculator: An efficient tool for large-scale flux mode computation. Bioinformatics 32(8): 1265- 1266.
  • Kloek AT, van Setten J, van der Ende A, Bots ML, Asselbergs FW, Seron MV, Brouwer MC, van de Beek D, Ferwerda B: Exome array analysis of susceptibility to pneumococcal meningitis. Scientific Reports 6: 29351.
  • Kofink D, Eppinga R, Hoefer I, Boersma H, Van der Harst P, Pasterkamp G, Asselbergs F: Metabolic profiles in cardiovascular patients: Predicting recurrent events. European Heart Journal 37(Suppl): 1389-1390.
  • Kretschmer T, Sentse M, Meeus W, Verhulst FC, Veenstra R, Oldehinkel AJ: Configurations of adolescents' peer experiences: Associations with parent-child relationship quality and parental problem behavior. Journal of Research on Adolescence 26(3): 474- 491.
  • Kroon M, Lameijer EW, Lakenberg N, Hehir-Kwa JY, Thung DT, Slagboom PE, Kok JN, Ye K: Detecting dispersed duplications in highthroughput sequencing data using a database-free approach. Bioinformatics 32(4): 505-510.
  • Lacko M, Voogd AC, van de Goor RC, Roelofs HM, Te Morsche RH, Bouvy ND, Peters WH, Manni JJ: Genetic polymorphisms in UDPglucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland. Head Neck 38 (Suppl 1): E717-E723.
  • Langenhof MR, Komdeur J, Oldehinkel AJ: Effects of parenting quality on adolescents' personality resemblance to their parents. The TRAILS study. Journal of Adolescence 51: 163-175.
  • Laurin C, Boomsma D, Lubke G: The use of vector bootstrapping to improve variable selection precision in lasso models. Statistical Applications in Genetics and Molecular Biology 15(4): 305-320.
  • Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, Tyrer J, Beesley J, Ramus SJ, Li QY, Delgado MK, et al.: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nature Communications 7: 12675.
  • Leeuwen van EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, et al.: Meta-analysis of 49 549 individuals imputed with the 1000 genomes project reveals an exonic damaging variant in angptl4 determining fasting TG levels. Journal of Medical Genetics 53(7): 441-449.
  • Lei JP, Rudolph A, Moysich KB, Behrens S, Goode EL, Bolla MK, Dennis J, Dunning AM, Easton DF, Wang Q, et al.: Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: A pooled analysis of 42,510 cases and 40,577 controls from the breast cancer association consortium. Human Genetics 135(1): 137-154.
  • Li Y, Oosting M, Deelen P, Ricano-Ponce I, Smeekens S, Jaeger M, Matzaraki V, Swertz MA, Xavier RJ, Franke L, et al.: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nature Medicine 22(8): 952-960.
  • Li MK, Rothwell R, Vermaat M, Wachsmuth M, Schroder R, Laros JFJ, van Oven M, de Bakker PIW, Bovenberg JA, van Duijn CM, et al.: Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: Support for a variable-size bottleneck. Genome Research 26(4): 417-426.
  • Li Y, Oosting M, Smeekens SP, Jaeger M, Aguirre-Gamboa R, Le KTT, Deelen P, Ricano-Ponce I, Schoffelen T, Jansen AFM, et al.: A functional genomics approach to understand variation in cytokine production in humans. Cell 167(4): 1099-1110.e1014.
  • Ligthart S, Steenaard RV, Peters MJ, van Meurs JBJ, Sijbrands EJG, Uitterlinden AG, Bonder MJ, Hofman A, Franco OH, Dehghan A, et al.: Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes. Diabetologia 59(5): 998-1006.
  • Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan WH, et al.: DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biology 17(1): 255.
  • Lin BD, Willemsen G, Abdellaoui A, Bartels M, Ehli EA, Davies GE, Boomsma DI, Hottenga JJ: The genetic overlap between hair and eye color. Twin Research and Human Genetics 19(6): 595-599.
  • Lin BD, Hottenga JJ, Abdellaoui A, Dolan CV, de Geus EJ, Kluft C, Boomsma DI, Willemsen G: Causes of variation in the neutrophillymphocyte and platelet-lymphocyte ratios: A twin-family study. Biomark Med 10: 10.
  • Liu F, Hamer MA, Deelen J, Lall JS, Jacobs L, van Heemst D, Murray PG, Wollstein A, de Craen AJM, Uh HW, et al.: The mc1r gene and youthful looks. Current Biology 26(9): 1213-1220.
  • Maas RPPWM, Schieving JH, Schouten M, Kamsteeg EJ, van de Warrenburg BPC: The genetic homogeneity of cams syndrome: Four new patients with the c.2452G > a(p.Glu818Lys) mutation in the ATP1A3 gene. Pediatric Neurology 59: 71-75.
  • Mbakwa CA, Scheres L, Penders J, Mommers M, Thijs C, Arts ICW: Early life antibiotic exposure and weight development in children. Journal of Pediatrics 176: 105-113.
  • Mbarek H, Dolan CV, Boomsma DI: Two SNPs associated with spontaneous dizygotic twinning: Effect sizes and how we communicate them. Twin Research and Human Genetics 19(5): 418- 421. Mbarek H, Steinberg S, Nyholt DR, Gordon SD, Miller MB, McRae AF, Hottenga JJ, Day FR, Willemsen G, de Geus EJ, et al.: Identification of common genetic variants influencing spontaneous dizygotic twinning and female fertility. American Journal of Human Genetics 98(5): 898-908.
  • Merino-Martinez R, Norlin L, van Enckevort D, Anton G, Schuffenhauer S, Silander K, Mook L, Holub P, Bild R, Swertz M, et al.: Toward global biobank integration by implementation of the minimum information about biobank data sharing (MIABIS 2.0 core). Biopreservation and Biobanking 14(4): 298-306.
  • Middeldorp CM, Hammerschlag AR, Ouwens KG, Groen-Blokhuis MM, St Pourcain B, Greven CU, Pappa I, Tiesler CMT, Ang W, Nolte IM, et al.: A genome-wide association meta-analysis of attentiondeficit/hyperactivity disorder symptoms in population-based pediatric cohorts. Journal of the American Academy of Child and Adolescent Psychiatry 55(10): 896-905.
  • Milaneschi Y, Lamers F, Peyrot WJ, Abdellaoui A, Willemsen G, Hottenga JJ, Jansen R, Mbarek H, Dehghan A, Lu C, et al.: Polygenic dissection of major depression clinical heterogeneity. Molecular Psychiatry 21(4): 516-522.
  • Milano A, Blom MT, Lodder EM, van Hoeijen DA, Barc J, Koopmann TT, Bardai A, Beekman L, Lichtner P, van den Berg MP, et al.: Sudden cardiac arrest and rare genetic variants in the community. Circ Cardiovasc Genet 9(2): 147-153.
  • Minikel EV, Vallabh SM, Lek M, Estrada K, Samocha KE, Sathirapongsasuti JF, McLean CY, Tung JY, Yu LPC, Gambetti P, et al.: Quantifying prion disease penetrance using large population control cohorts. Science Translational Medicine 8(322): 12.
  • Monlong J. M, C., Rouleau, G., Cossette, P., Girard, S.L., Bourque, G.: Human copy number variants are enriched in regions of lowmappability. BioRxiv: 034165.
  • Mostert JC, Shumskaya E, Mennes M, Onnink AMH, Hoogman M, Kan CC, Vasquez AA, Buitelaar J, Franke B, Norris DG: Characterising resting-state functional connectivity in a large sample of adults with ADHD. Progress in Neuro-Psychopharmacology & Biological Psychiatry 67: 82-91.
  • Nieuwboer HA, Pool R, Dolan CV, Boomsma DI, Nivard MG: Gwis: Genome-wide inferred statistics for functions of multiple phenotypes. American Journal of Human Genetics 99(4): 917-927.
  • Nivard MG, Middeldorp CM, Lubke G, Hottenga JJ, Abdellaoui A, Boomsma DI, Dolan CV: Detection of gene-environment interaction in pedigree data using genome-wide genotypes. European Journal of Human Genetics 24(12): 1803-1809.
  • Nygaard M, Debrabant B, Tan QH, Deelen J, Andersen-Ranberg K, de Craen AJM, Beekman M, Jeune B, Slagboom PE, Christensen K, et al.: Copy number variation associates with mortality in long-lived individuals: A genome-wide assessment. Aging Cell 15(1): 49-55.
  • Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P, Chen GB, Emilsson V, Meddens SFW, et al.: Genome-wide association study identifies 74 loci associated with educational attainment. Nature 533(7604): 539-542.
  • Onnink AMH, Franke B, van Hulzen K, Zwiers MP, Mostert JC, Schene AH, Heslenfeld DJ, Oosterlaan J, Hoekstra PJ, Hartman CA, et al.: Enlarged striatal volume in adults with ADHD carrying the 9-6 haplotype of the dopamine transporter gene DAT1. Journal of Neural Transmission 123(8): 905-915.
  • Otowa T, Hek K, Lee M, Byrne EM, Mirza SS, Nivard MG, Bigdeli T, Aggen SH, Adkins D, Wolen A, et al.: Meta-analysis of genome-wide association studies of anxiety disorders. Molecular Psychiatry 21(10): 1485.
  • Pang C, van Enckevort D, de Haan M, Kelpin F, Jetten J, Hendriksen D, de Boer T, Charbon B, Winder E, van der Velde KJ, et al.: MOLGENIS/connect: A system for semi-automatic integration of heterogeneous phenotype data with applications in biobanks. Bioinformatics 32(14): 2176-2183.
  • Pankratz N, Schick UM, Zhou Y, Zhou W, Ahluwalia TS, Allende ML, Auer PL, Bork-Jensen J, Brody JA, Chen MH, et al.: Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits. Nature Genetics 48(8): 867-876.
  • Pelttari LM, Khan S, Vuorela M, Kiiski JI, Vilske S, Nevanlinna V, Ranta S, Schleutker J, Winqvist R, Kallioniemi A, et al.: RAD51b in familial breast cancer. PLoS One 11(5): e0153788.
  • Peters MJ, Ramos YF, den Hollander W, Schiphof D, Hofman A, Uitterlinden AG, Oei EH, Slagboom PE, Kloppenburg M, Bloem JL, et al.: Associations between joint effusion in the knee and gene expression levels in the circulation: A meta-analysis. F1000Res 5: 109.
  • Petridis C, Brook MN, Shah V, Kohut K, Gorman P, Caneppele M, Levi D, Papouli E, Orr N, Cox A, et al.: Genetic predisposition to ductal carcinoma in situ of the breast. Breast Cancer Research 18(1): 22.
  • Pirastu N, Kooyman M, Robino A, van der Spek A, Navarini L, Amin N, Karssen LC, van Duijn CM, Gasparini P: Non-additive genome-wide association scan reveals a new gene associated with habitual coffee consumption. Scientific Reports 6: 31590.
  • Pirastu N, Kooyman M, Traglia M, Robino A, Willems SM, Pistis G, Amin N, Sala C, Karssen LC, van Duijn CM, et al.: A genome-wide association study in isolated populations reveals new genes associated to common food likings. Rev Endocr Metab Disord 17(2): 209-219.
  • Pitsiladis YP, Tanaka M, Eynon N, Bouchard C, North KN, Williams AG, Collins M, Moran CN, Britton SL, Fuku N, et al.: Athlome project consortium: A concerted effort to discover genomic and other "omic" markers of athletic performance. Physiological Genomics 48(3): 183-190.
  • Plantinga M, Birnie E, Abbott KM, Sinke RJ, Lucassen AM, Schuurmans J, Kaplan S, Verkerk MA, Ranchor AV, van Langen IM: Populationbased preconception carrier screening: How potential users from the general population view a test for 50 serious diseases. European Journal of Human Genetics 24(10): 1417-1423.
  • Poortvliet RKE, van Peet PG, de Craen AJM, Mertens BJA, Mooijaart SP, Wijsman LW, Drewes YM, Ford I, Sattar N, Jukema JW, et al.: Risk stratification and treatment effect of statins in secondary cardiovascular prevention in old age: Additive value of n-terminal pro-b-type natriuretic peptide. European Journal of Preventive Cardiology 23(10): 1104-1113.
  • Praagman J, Adolphs APJ, van Rossum CTM, Sluijs I, van der Schouw YT, Beulens JWJ: Reproducibility and relative validity of a FFQ to estimate the intake of fatty acids. British Journal of Nutrition 115(12): 2154-2161.
  • Quteineh L, Preisig M, Rivera M, Milaneschi Y, Castelao E, GholamRezaee M, Vandenberghe F, Saigi-Morgui N, Delacretaz A, Cardinaux JR, et al.: Association of crtc1 polymorphisms with obesity markers in subjects from the general population with lifetime depression. Journal of Affective Disorders 198: 43-49.
  • Rebbeck TR, Friebel TM, Mitra N, Wan F, Chen S, Andrulis IL, Apostolou P, Arnold N, Arun BK, Barrowdale D, et al.: Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women. Breast Cancer Research 18(1): 112.
  • Rest van de O, Schutte BAM, Deelen J, Stassen SAM, van den Akker EB, van Heemst D, Dibbets-Schneider P, van Dipten-Van Der Veen RA, Kelderman M, Hankemeier T, et al.: Metabolic effects of a 13-weeks lifestyle intervention in older adults: The growing old together study. Aging-Us 8(1): 111-126.
  • Ricano-Ponce I, Zhernakova DV, Deelen P, Luo O, Li XW, Isaacs A, Karjalainen J, di Tommaso J, Borek ZA, Zorro MM, et al.: Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs. Journal of Autoimmunity 68: 62-74.
  • Roi la C, Kretschmer T, Dijkstra JK, Veenstra R, Oldehinkel AJ: Disparities in depressive symptoms between heterosexual and lesbian, gay, and bisexual youth in a Dutch cohort: The TRAILS study. J Youth Adolesc 45(3): 440-456.
  • Rooij van IA, van der Zanden LF, Bongers EM, Renkema KY, Wijers CH, Thonissen M, Dokter EM, Marcelis CL, de Blaauw I, Wijnen MH, et al.: AGORA, a data- and biobank for birth defects and childhood cancer. Birth Defects Res A Clin Mol Teratol 106(8): 675-684.
  • Roos L, van Dongen J, Bell CG, Burri A, Deloukas P, Boomsma DI, Spector TD, Bell JT: Integrative DNA methylome analysis of pancancer biomarkers in cancer discordant monozygotic twin-pairs. Clinical Epigenetics 8: 7.
  • Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Ter Horst R, Jansen T, Jacobs L, Bonder MJ, et al.: Linking the human gut microbiome to inflammatory cytokine production capacity. Cell 167(4): 1125-1136 e1128.
  • Schutte BAM, van den Akker EB, Deelen J, van de Rest O, van Heemst D, Feskens EJM, Beekman M, Slagboom PE: The effect of standardized food intake on the association between BMI and 1hNMR metabolites. Scientific Reports 6: 38980.
  • Shi J, Zhang Y, Zheng W, Michailidou K, Ghoussaini M, Bolla MK, Wang Q, Dennis J, Lush M, Milne RL, et al.: Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. International Journal of Cancer 139(6): 1303-1317.
  • Silvestri V, Barrowdale D, Mulligan AM, Neuhausen SL, Fox S, Karlan BY, Mitchell G, James P, Thull DL, Zorn KK, et al.: Male breast cancer in BRCA1 and BRCA2 mutation carriers: Pathology data from the consortium of investigators of modifiers of BRCA1/2. Breast Cancer Research 18: 15.
  • Slieker RC, van Iterson M, Luijk R, Beekman M, Zhernakova DV, Moed MH, Mei HL, van Galen M, Deelen P, Bonder MJ, et al.: Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms. Genome Biology 17: 13.
  • Sluik D, Geelen A, de Vries JHM, Eussen S, Brants HAM, Meijboom S, van Dongen M, Bueno-de-Mesquita HB, Wijckmans-Duysens NEG, van 't Veer P, et al.: A national FFQ for the Netherlands (the FFQ-NL 1.0): Validation of a comprehensive FFQ for adults. British Journal of Nutrition 116(5): 913-923.
  • Stringer S, Minica CC, Verweij KJH, Mbarek H, Bernard M, Derringer J, van Eijk KR, Isen JD, Loukola A, Maciejewski DF, et al.: Genome-wide association study of lifetime cannabis use based on a large metaanalytic sample of 32330 subjects from the international cannabis consortium. Translational Psychiatry 6: 9.
  • Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, et al.: Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics 48(10): 1151- 1161.
  • Thesing C, Bot M, Penninx B, Giltay E: Polyunsaturated fatty acids in major depressive disorders. Bipolar Disorders 18: 139-140.
  • Tilborg van TC, Broekmans FJ, Pijpe A, Schrijver LH, Mooij TM, Oosterwijk JC, Verhoef S, Garcia EBG, van Zelst-Stams WA, Adank MA, et al.: Do BRCA1/2 mutation carriers have an earlier onset of natural menopause? Menopause 23(8): 903-910.
  • Treur JL, Taylor AE, Ware JJ, Nivard MG, Neale MC, McMahon G, Hottenga JJ, Baselmans BM, Boomsma DI, Munafo MR, et al.: Smoking and caffeine consumption: A genetic analysis of their association. Addict Biol: Epub ahead of print.
  • Udden J, Snijders TM, Fisher SE, Hagoort P: A common variant of the cntnap2 gene is associated with structural variation in the left superior occipital gyrus. Brain Lang: Epub ahead of print.
  • Valls Seron M, Ferwerda B, Engelen-Lee J, Geldhoff M, Jaspers V, Zwinderman AH, Tanck MW, Baas F, van der Ende A, Brouwer MC, et al.: V-AKT murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. Acta Neuropathol Commun 4(1): 50.
  • Vinciotti V, Wit EC, Jansen R, de Geus E, Penninx BWJH, Boomsma DI, 't Hoen PAC: Consistency of biological networks inferred from microarray and sequencing data. Bmc Bioinformatics 17: 10.
  • Vos JR, Oosterwijk JC, Aalfs CM, Rookus MA, Adank MA, van der Hout AH, van Asperen CJ, Garcia EBG, Mensenkamp AR, Jager A, et al.: Bias explains most of the parent-of-origin effect on breast cancer risk in BRCA1/2 mutation carriers. Cancer Epidemiology Biomarkers & Prevention 25(8): 1251-1258.
  • Vries de PS, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, Tang WH, Teumer A, Marioni RE, Grossmann V, et al.: A metaanalysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Human Molecular Genetics 25(2): 358-370.
  • Vrijen C, Hartman CA, Oldehinkel AJ: Slow identification of facial happiness in early adolescence predicts onset of depression during 8 years of follow-up. Eur Child Adolesc Psychiatry 25(11): 1255- 1266.
  • Ware JJ, Chen XN, Vink J, Loukola A, Minica C, Pool R, Milaneschi Y, Mangino M, Menni C, Chen JC, et al.: Genome-wide meta-analysis of cotinine levels in cigarette smokers identifies locus at 4q13.2. Scientific Reports 6: 20092.
  • Warrenburg van de BP, Schouten MI, de Bot ST, Vermeer S, Meijer R, Pennings M, Gilissen C, Willemsen MA, Scheffer H, Kamsteeg EJ: Clinical exome sequencing for cerebellar ataxia and spastic paraplegia uncovers novel gene-disease associations and unanticipated rare disorders. European Journal of Human Genetics 24(10): 1460-1466.
  • Weiss A, Baselmans BML, Hofer E, Yang JY, Okbay A, Lind PA, Miller MB, Nolte IM, Zhao W, Hagenaars SP, et al.: 1 personality polygenes, positive affect, and life satisfaction. Twin Research and Human Genetics 19(5): 407-417.
  • Willemse EAJ, Durieux-Lu S, van der Flier WM, Pijnenburg YAL, de Jonge R, Teunissen CE: Stability of progranulin under pre-analytical conditions in serum and cerebrospinal fluid. Journal of Alzheimer’s Disease 53(1): 107-116.
  • Winter de AF, Visser L, Verhulst FC, Vollebergh WAM, Reijneveld SA: Longitudinal patterns and predictors of multiple health risk behaviors among adolescents: The trails study. Preventive Medicine 84: 76-82.
  • Woo YJ, Wang T, Guadalupe T, Nebel RA, Vino A, Del Bene VA, Molholm S, Ross LA, Zwiers MP, Fisher SE, et al.: A common cyfip1 variant at the 15q11.2 disease locus is associated with structural variation at the language-related left supramarginal gyrus. PLoS One 11(6): e0158036.
  • Wyszynski A, Hong CC, Lam K, Michailidou K, Lytle C, Yao S, Zhang Y, Bolla MK, Wang Q, Dennis J, et al.: An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating igfbp5 expression. Human Molecular Genetics 25(17): 3863-3876.
  • Yu B, Pulit SL, Hwang SJ, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A, et al.: Rare exome sequence variants in clcn6 reduce blood pressure levels and hypertension risk. Circ Cardiovasc Genet 9(1): 64-70.
  • Zayats T, Jacobsen KK, Kleppe R, Jacob CP, Kittel-Schneider S, Ribases M, Ramos-Quiroga JA, Richarte V, Casas M, Mota NR, et al.: Exome chip analyses in adult attention deficit hyperactivity disorder. Translational Psychiatry 6(10): e923.
  • Zeng C, Guo XY, Long JR, Kuchenbaecker KB, Droit A, Michailidou K, Ghoussaini M, Kar S, Freeman A, Hopper JL, et al.: Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Research 18(1): 64.
  • Zhao ZG, Wen WQ, Michailidou K, Bolla MK, Wang Q, Zhang B, Long JR, Shu XO, Schmidt MK, Milne RL, et al.: Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. Cancer Causes & Control 27(5): 679- 693.