Atlases - Omics, Imaging

The BBMRI-Omics Atlas is an interactive webtool that allows you to explore the comprehensive collection of public atlases on the relationship between molecular data and disease phenotypes. The tool allows you to explore associations between available data layers within BBMRI-Omics, as well as associations between molecular data layers and investigated phenotypes.

What is BBMRI-NL’s BBMRI-Omics Atlas?

The BBMRI-Omics Atlas is an interactive webtool to explore the comprehensive collection of public atlases on the relationship between molecular data and disease phenotypes. These public atlases together contain information from extensive datasets at the genome, epigenome, transcriptome and metabolome level for ten thousand individuals from multiple Dutch biobanks. BBMRI researchers have identified a plethora of links between molecular layers of cellular organization, by screening these extensive datasets in large analyses. This led them to uncover insight into how molecular pathways are involved in health and disease. The Omics Atlas is a result of this huge endeavour.

The Omics Atlas has been made accessible to the general public as an online resource: the associations between the available data layers within BBMRI-Omics (genetics, DNA methylation, transcriptome, metabolome) can be explored, as well as the associations between the molecular data layers and investigated phenotypes (for example Type 2 diabetes, educational level, smoking).

Why BBMRI-NL’s BBMRI-Omics Atlas?

To integrate the identified associations between the different omics levels in a straightforward, intuitive fashion, the complex association data are shown as an interactive, layered network (see picture below), in addition to text tables as is standard for omics browsers. So instead of describing all the data and associations available, the Atlas shows a layered network image of the associations requested. Users can then determine themselves what details they want to look at further and how. For example, the network view provides users with comprehensive insights in the regulation of gene expression by regulatory elements and genetic variants. The Atlas provides researchers with a truly unique repository within the life sciences that allows them to view how variations at the level of the DNA percolate through each layer and ultimately affect our health.